04-2-1132-2017/2022
 
Priority: 1
   
Status: Extended
 
Biomedical and Radiation-Genetic Studies Using Different Types
of Ionizing Radiation

Leader:     G.V. Mitsyn
Deputy:     S.V. Shvidky

Participating countries and international organizations:
Moldova, Czech Republic, India, Poland, Romania, Russia, South Africa


Issues addressed and main goals of research:
Mdico-biological and clinical research for the proton radiotherapy of cancer patients. Formation of an experimental data base in the field of radiation mutagenesis in the animal germ cells.

Expected results in the current year:
  • Continuation of clinical researches on proton therapy of cancer patients in Room 1. Evaluation of the effectiveness of the conducted radiation treatment of different neoplasms.

  • Work to increase the functional capability of the developed 3D treatment planning software and its clinical tests in the treatment sessions.

  • Design and construction of the prototype equipment for the dynamic conformal irradiation of deep-seated tumours with the proton beam.

  • Development and improvement of detectors and tools for the clinical dosimetry of the medical hadron beams.

  • Continuation of research to determine forms of fibroblast cell death depending on the dose of ionizing radiation.

  • Study of mechanisms of functional and neurochemical disorders in the central nervous system under the action of radiation with different linear energy transfer.

  • Mastering of new methodes for evaluation of the effectiveness of the cytotoxic action of nanoparticles on tumour cells.

  • Continuation of the molecular analysis of gamma- and neutron-induced intragenic structural changes in germline cells.

  • Start of the sequence analysis of inherited DAN changes at the genome level of the offspring.

  • Beginning of the work on the analysis of the transcriptome in somatic cells differing in radiosensitivity.
List of projects:
  Project Leader Priority
(period of realisation)
1. Further development of methods,
technologies, schedule modes and
delivery of radiotherapy
G.V. Mitsyn
K.Sh. Voskanyan
1   (2017-2022)
2. RADIOGENE: Molecular genetics of
radiation-induced changes at the gene,
genome and transcriptome level in
Drosophila melanogaster
I.D. Alexandrov 1   (2017-2022)

List of Activities
  Activity or Experiment Leaders
Status
      Laboratory or other
    Division of JINR
Main researchers
1. Further development of methods,
technologies, schedule modes and
delivery of radiotherapy
G.V. Mitsyn
K.Sh. Voskanyan
R&D
  DLNP A.V. Agapov, O.V. Belov, I.V. Alexandrova, K. Belokopytova, V.M. Breyev, D.M. Borovich, T.L. Demakova, G.V. Donskaya, V.N. Gaevsky, A.E. Ivanova, Ye.I. Luchin, I.I. Klochkov, I. Khosenova, I.Ye. Miller, A.G. Molokanov, K. Oancea, S.A. Pisareva, A.V. Rzyanina, K.N. Shipulin, M.A. Tseytlina
2. RADIOGENE: Molecular genetics
of radiation-induced changes at the
gene, genome and transcriptome
level in Drosophila melanogaster
I.D. Alexandrov
R&D
  DLNP M.V. Alexandrova, K.P. Afanasyeva, A.E. Ivanova, N.E. Kharchenko, S.V. Korablinova, L.N. Korovina, Ye.V. Kravchenko, N.V. Orlova, A.N. Rusakovich, O.P. Solodilova

Collaboration
Country or International
Organization
City Institute or Laboratory
Czech Republic Prague PTC  
    ADVACAM  
  Rez UJV  
Moldova Chisinau MSU  
Poland Otwock (Swierk) NCBJ  
  Poznan GPCC  
Romania Bucharest IFIN-HH  
Russia Moscow IBMP RAS  
    DMS RAS  
    VIGG RAS  
    FMBC  
  Dubna RDH-9  
  Rostov-on-Don SFedU  
South Africa Faure iThemba LABS