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of Ionizing Radiation
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Leaders: |
G.V. Mitsyn |
| Deputy: | S.V. Shvidky |
Participating countries and international organizations:
Belgium, China, Czech Republic, Moldova, Poland, Romania, Russia, South Africa.
Issues addressed and main goals of research:
Biomedical and clinical research of proton radiotherapy for cancer treatment. Formation of the experimental data base in the field of radiation mutagenesis in animal germ cells.
Expected results in the current year:
- Evaluation of effectiveness of conducted radiation treatment of different neoplasms.
- Increase of functional capability of the developed 3D treatment planning software.
- Design and construction of prototype equipment for dynamic conformal irradiation of deep-seated tumours with the proton beam.
- Development and improvement of detectors and tools for clinical dosimetry of medical hadron beams.
- Continuation of research to determine forms of fibroblast cell death depending on the dose of ionizing radiation.
- Study of mechanisms of functional and neurochemical disorders in the central nervous system during exposure to radiation with different linear energy transfer.
- Mastering of new methods for evaluation of effectiveness of cytotoxic activity of nanoparticles on tumour cells.
- Studies of difference in radiobiological reactions for normal and cancer cells irradiated by flash technique.
- Continuation of the molecular analysis of gamma- and neutron-induced intragenic structural changes in germline cells.
- Continuation of the sequence analysis of inherited DAN changes at the genome level of the offspring.
- Continuation of the work on the analysis of the transcriptome in somatic cells differing in radiosensitivity.
- Determination of the secondary structure of the Dsup protein using SAXS, DLS, and circular dichroism methods.
- Transcriptome analysis of D.melanogaster strains and human cell line HEK293 expressing Dsup protein.
- Assessment of metabolic activity (MTT-test) and apoptosis induction (according to caspase-3/7 activity) in human HEK293 culture cells expressing Dsup, determination of the level of reactive oxygen species in cells.
- Development of a project of a specialized isochronous cyclotron for proton therapy.
- Measurements of the magnetic field of the MC1 bending magnet for the transport line of the AIC-144, Krakow, Poland.
| List of projects: | |||
| Project | Leader | Priority (period of realisation) |
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| 1. | Further development of methods, technologies, schedule modes and provision of radiotherapy |
G.V. Mitsyn | 1 (2017-2023) |
| 2. | RADIOGENE: Molecular genetics of radiation-induced changes at the gene, genome and transcriptome level in Drosophila melanogaster |
K.P. Afanasyeva Deputy: A.E. Rusakovich |
1 (2017-2023) |
| 3. | Study of the radioprotective properties of the Damage supressor (Dsup) protein on a model organism D.melanogaster and the human cell culture HEK293 |
E.V. Kravchenko | 1 (2021-2023) |
| List of Activities | |||||
| Activity or Experiment | Leaders | ||||
| Laboratory or other Division of JINR |
Main researchers | ||||
| 1. | Further development of methods, technologies, schedule modes and provision of radiotherapy |
G.V. Mitsyn |
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DLNP |
A.V. Agapov, O.V. Belov, I.V. Alexandrova, G.A. Andreev, K. Belokopytova, V.M. Breev, G.V. Donskaya, V.N. Gaevsky, Ye.A. Gritskova, Ye.I. Luchin, I.I. Klochkov, I. Khosenova, I.Ye. Miller, A.G. Molokanov, S.A. Pisareva, A.V. Rzyanina, K.N. Shipulin, S.V. Shvidky |
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| 2. | RADIOGENE: Molecular genetics of radiation-induced changes at the gene, genome and transcriptome level in Drosophila melanogaster |
I.D. Alexandrov |
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DLNP |
M.V. Alexandrova, K.P. Afanasyeva, N.E. Kharchenko, S.V. Korablinova, L.N. Korovina, N.V. Orlova, A.N. Rusakovich, O.P. Solodilova |
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| 3. | Study of the radioprotective properties of the Damage supressor (Dsup) protein on a model organism D.melanogaster and the human cell culture HEK293 | E.V. Kravchenko |
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DLNP |
T.O. Azorskaya, O.A. Kuldoshina, A.V. Rzyanina, A.S. Yakunenko, M.P. Zarubin? R.A. Tarasov, A.S. Yakhnenko |
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FLNR |
T.N. Murugova |
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| 4. | Development of methods and programs for creating cyclotron-type accelerators. Development and upgrade of cyclotrons for medical application | G.A. Karamysheva |
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DLNP |
K.S. Bunyatov, A.F. Chesnov, S.B. Fedorenko, R.V. Galkin, A.L. Gibinsky, S.V. Gursky, S.N. Dolya, G.G. Kazakova, O.V. Karamyshev, I.N. Kiyan, O.E. Lepkina, O.V. Lomakina, I.V. Lyapin, V.A. Malinin, D.S. Petrov, D.V. Popov, G.D. Shirkov, S.G. Shirkov, V.L. Smirnov, A.S. Vorozhtsov, S.B. Vorozhtsov |
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| MLIT | I.V. Amirhanov, T.V. Karamysheva | ||
Collaboration
| Country or International Organization | City | Institute or Laboratory |
| Belgium | Louvain-la-Neuve | IBA |
| China | Hefei | IPP CAS |
| Czech Republic | Prague | ADVACAM |
| PTC | ||
| Rez | UJV | |
| Moldova | Chisinau | MSU |
| Poland | Krakow | INP PAS |
| Otwock (Swierk) | NCBJ | |
| Poznan | GPCC | |
| Romania | Bucharest | IFIN-HH |
| Cluj-Napoca | UBB | |
| Iasi | UAIC | |
| Russia | Moscow | FMBC |
| IBMP RAS | ||
| VIGG RAS | ||
| Puschino | ITEB RAS | |
| Rostov-on-Don | SFedU | |
| Saratov | SSU | |
| South Africa | Somerset West | iThemba LABS |
