08-2-1127-2016
   
  
Advanced Studies of Systems of New-Generation
Accelerators and Colliders for Fundamental and Applied Research
 
   
Theme leaders:     G.V. Trubnikov
G.D. Shirkov
B.N. Gikal

Participating countries and international organizations:
Belarus, Belgium, CERN, China, Georgia, Germany, Italy, Moldova, Russia, Slovakia, South Africa.


The problem under study and the main purpose of the research:
Development of the systems and elements of new generation accelerators at JINR, applied research on  accelerators. Participation in the development of  the international accelerator complexe projects. Participation in the development of the concept of establishment a pilot scientific and clinical center for proton therapy.
 
Project in the theme:
  Name of the project Project Leaders Project code
Laboratory   Responsible from laboratories Status
1. Сreation of test benches
for testing 
individual systems of the MSC-230 cyclotron

G. A. Karamysheva 
S.L. Yakovenko

08-2-1127-1-2024/2025

Technical project
DLNP A.F. Chesnov, S.N. Dolya, I.V. Evseeva, S.A. Fedorenko,R.V. Galkin, V.A.Gerasimov, A.L.Gonshior, S.V. Gursky, G.G. Kazakova, O.V. Karamyshev, N.V. Kirichkov I.N. Kiyan, O.E. Lepkina, O.V. Lomakina, I.D. Lyapin, V.A. Malinin, D.A. Malysh, I.M.Palnikov, D.S. Petrov, D.V. Popov, D.V. Rogozin, V.M. Romanov, N.A. Rybakov, L.D. Sedov, A.A. Sinitsa, G.M. Skripka, G.D. Shirkov, S.G. Shirkov, A.I. Vlasov

VBLHEP V.V. Borisov, G.G. Khodzhibagiyan, D.N. Nikiforov, M.S. Novikov

MLIT   T.V. Karamysheva

Brief annotation and scientific rationale:
The development of the superconducting proton cyclotron MSC-230 will create a source of intense proton beams, opens up possibilities to modernize the equipment for precise control and delivery of high dose rate for studies by the Flash therapy method. MSC-230 may become the first model for a series of specialized medical accelerators of this type. The cyclotron should provide a current  up to 1 μA in continuous mode and up to 10 μA in pulsed mode at the proton energy of 230 MeV.

The modeling and testing prototypes of the cyclotron elements, such as a proton source and a deflector, on the test benches and the developing of the magnetic field measurement system are necessary for the successful launch of the MSC-230 cyclotron.

The project actuality  is determined primarily by the importance of creating adomestic accelerator for proton therapy using the most modern methods, distinguished by a unique beam intensity, as well as the relevance of medical and biological research that will be conducted at MSC-230.

Expected results upon completion of the project:
The MSC-230 cyclotron commissioning on the beam design parameters necessary for testing equipment and treating patients with modern proton therapy methods.

Expected results of the project this year:
The study of the operability of individual cyclotron systems: deflector, proton source. Development of the magnetic field measurement system including the calibration magnet. Determination of medical and technical conditions for the  proton therapy center projecting.

Activities of the theme:

  Name of the activity Leaders
Implementation period
Laboratory    Responsible from laboratories Status
1. Further development of methods, technologies, schedule modes and provision of radiotherapy

G.V. Mitsyn

2024-2025

R&D
DLNP A.V. Agapov, I.V. Alexandrova, K.V. Belokopytova, V.M. Breev, S.N.Dima, G.V. Donskaya, V.N. Gaevsky, E.A. Gritskova, S.A. Gustov, M.D. Indiukova, I.I. Klochkov, A.G. Molokanov, S. A. Pisareva., A.V. Rzyanina, S.V. Shvidkiy, S.S. Uglova

Brief annotation and scientific rationale:
This project is a continuation of the medical and biological research started at the JINR Laboratory of Nuclear Problems in 1967 using proton beams. The project includes the following works: participation in the Determination of medical and technical conditions for the project to create a proton therapy center, calculation of beam transportation channels to the irradiation units, development and manufacture of the detectors for dosimetric support of flash therapy, development and testing of all technological stages of planning and conducting proton therapy. It is planned to conduct medical and biological research at the DLNP linear electron accelerator (LINAC-200), which is supposed to form an electron beam with an energy of 20-25 MeV for irradiating cell cultures and small laboratory animals (mice, rats).

Expected results of the activity upon completion:
The manufacturing and testing of proton beam Bragg peak modifiers (comb filters) using 3D printing for the future radiological center based on the MSC-230 accelerator. Manufacturing and testing of thin-walled multi-wire and strip ionization chambers. Formation of an electron beam with an energy of 20-25 MeV on the LINAC-200 accelerator for medical and biological research.


Expected results of the activity in the current year:
To continue conducting radiobiological research in a wide range of areas: the use of heavy metal nanoparticles as radiomodifiers during radiotherapy, the study of the radiobiological foundations of the flash effect, studies of the effect of ionizing radiation of various qualities on the structures and functions of the central nervous system, and others.

2. R&D of Photoinjecting systems M.A. Nozdrin

2024-2025

Technical Proposal
Realization
DLNP A.V. Afanasiev, A.S. Dyatlov, P.P. Zhuravlev, D.S. Shokin, K.E. Yunenko

VBLHEP V.V. Bleco, N.I. Garanzha, J. Huran, A.V. Skrypnik, V.G. Shabratov

Brief annotation and scientific rationale:
The most modern free electron lasers, as well as other facilities which require high quality electron beam, the photocathode injectors are being used. Such injectors allow to obtain higher beam quality than thermoemission ones. Replacement of the thermoinjector of the LINAC-200 accelerator to the photoinjector is being considered. This will result in the beam emittance reduction, will give more flexibility in beam temporary profile and eventually will allow to construct LINAC-200-based FEL in the range from far IR to UV and soft X-rays.


Expected results of the activity upon completion:
The photoinjector testbench with the electron energy of up to 6 MeV based on S band RF gun construction.  The possibility of replacing the thermoinjector of the LINAC-200 accekerator with a photoinjector to improve beam quality and variability of its parameters conclusion.
Research of the quantum efficiency of various “transparent” photocathodes based on ultrathin carbon films: depending on deposition method, carbon phases and structures, doping elements and their concentration, cathode shape etc.


Expected results of the activity in the current year:
Design and assembling of the testbench equipment: laser beamline, vacuum and RF systems, synchronization of the laser with RF system, beam focusing and diagnostics. Design of the safety systems.

3. Participation in the development of the concept and joint project with FMBA of Russia for the creation of a pilot scientific and clinical center for proton therapy

G.D. Shirkov

2024-2025

Preparation of project
DLNP S.G. Shirkov, S.L. Yakovenko

VBLHEP   L.Yu. Stolypina

Brief annotation and scientific rationale:
The Federal Medical and Biological Agency (FMBA) of Russia expressed its intention to take part together with JINR in the development of a joint concept (and in the future, a project) for the establishment of a pilot scientific and clinical center for proton therapy on the basis of the existing medical center No. 9 of the FMBA in Dubna and based on the MSC-230 accelerator being created at JINR. The objectives of the center will be development of modern methods and technologies of radiation therapy, medical technologies and diagnostics for the use of radiation therapy, advanced scientific research in the field of radiobiology, experimental irradiation and further treatment of patients.

Expected results of the activity upon completion:
Preparation of the project for establishment a proton therapy center.

Expected results of the activity in the current year:
Development of medical and technical conditions for the project of establishment a proton therapy center.

Collaboration
Country or International Organization City Institute or laboratory
Belarus Minsk INP BSU
    IP NASB
Belgium Louvain-la-Neuve IBA
CERN Geneva CERN
China Hefei ASIPP
Georgia Tbilisi HEPI-TSU
Germany Hamburg DESY
Italy Pisa INFN
Moldova Chisinau MSU
Russia Moscow FMBA
    FMBC
    IBMP RAS
  Nizhny Novgorod IAP RAS
  Petropavlovsk-Kamchatsky FRC GC RAS
    KSU
  Puschino ITEB RAS
  Saratov SSU
Slovakia Bratislava IEE SAS
South Africa Somerset West iThemba LABS